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Homopolymer-errors can be harmful for downstream analyses such as read-mapping (c.f. Chapter 3). However, in many cases, reads cannot be re-sequenced with newer technologies, or base-called with better base callers. Only the read sequences potentially containing homopolymer errors, are available for usage. In order to account for this sort of error, a simple pre-processing trick was developed: homopolymer compression (HPC).